When unstable Susan (Barbara Hershey) is tragically widowed she finds it impossible to care for her delinquent adolescent daughter Niki, forcing Billy (Reid Scott), her son, to care for his difficult younger sister. As the two begin to forge a healthy bond, well-intentioned Billy implements his own methods of treatment for Niki’s mental troubles. But when turmoil persists, Billy must grapple with his ideals and what may actually be best for his sister.
Reid Scott (VEEP) delivers a nuanced performance as Billy, the estranged brother forced into the responsibilities of parenthood. Sister brings the timely topic of youth and psychotropic drug prescription to the forefront with insight and grace.